ea0014oc12.2 | Diabetes | ECE2007
Thybo Christesen Henrik
, Hussain Khalid
, Svargo Lone
, Brock Jacobsen Bendt
, Brusgaard Klaus
Background: Congenital Hyperinsulinism (CHI) is genetically unexplained today in up to 50% of the patients with persistent or recurrent disease. The uncoupling protein 2 (UCP2) gene is a candidate gene for medical-responsive CHI, since knock out studies have shown that UCP2 deficiency leads to increased glucose-stimulated insulin secretion.Patients and methods: In a large series of 142 patients with transient, persistent or recurrent CHI, we examined for...